Brazil has dominated the rivalry and arrives heavily favored to advance, but this time the five-time champions will be facing a Chile team eager to show it can get past the round of 16 for the first time since its home tournament in 1962.
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The Brazilians know better not to take their opponents for granted.
"Now we get to the stage where the 90 minutes will be decisive, mistakes are not allowed or you will be going home," Brazil coach Dunga said. "Chile has been improving, it has a team with good players and will fight very hard to keep advancing."
Look for the Chileans to come out in full force as they look to give their coach his first victory in six chances against Brazil, but int he end look for Brazil to win easily, overpowering Chile with their offensive attack.
Player to watch for Brazil
Maicon The Inter Milan right back has been sensational for Brazil, helping to keep things tight at the back and lending support to the attack by making his trademark rampaging runs down the wing. He also scored one of the best goals of the tournament, in the first round against North Korea.
Player to watch for Chile
Jorge Valdivia The attacking midfielder has been one of the revelations of this tournament, his bright and inventive play helping Chile reach the second round. But can he inspire his country to victory over mighty Brazil?