Commercial Insight: Top 20 Oncology Therapy Brands In Australia Revenues Of Targeted Therapies Soar
Introduction
IntroductionThe Top 20 cancer therapy brands in Australia reached sales of about $545m in 2008, growing at a CAGR of 30% since 2005. Datamonitor forecasts this growth to slow down considerably to a CAGR of 5.6% between 2008 and 2018 mainly due to maturing markets and the entry of generics for several key products. Sales of the Top 20 brands are expected to reach a total of $940m in 2018.
Scope
*This report focuses on the Top 20 cancer therapy brands in Australia sales and volume forecasts to 2018
*Assessment of Australia-specific drivers and resistors likely to impact the market
*Future market outlook for individual products taking into account key market events, in particular indication expansion and patent expiry
*Case study examining the approval and reimbursement process in Australia
Highlights
forecasts that the molecular targeted therapies will continue to drive growth in the Australian Top 20 cancer therapies market over the forecast period 20082018, with sales increasing from $320m in 2008 to $750m 2018.
The highest-selling brand in Australia in 2008 was Herceptin (trastuzumab; Roche) with sales of just under $120m and a CAGR between 2005 and 2008 of 61%. This drug is well positioned in the HER-2-positive breast cancer market where it received an exceptional reimbursement status.
In 2018, the Australian Top 20 will be led by Rituxan/MabThera (rituximab; Roche) with sales of $225m, followed by Avastin (bevacizumab; Roche) and Herceptin with revenues of $190m and $160m, respectively. Avastin will be the fastest growing brand with a 20082018 CAGR of 38% due to aggressive indication expansion in the coming years.
Reasons to Purchase
*Identify key opportunities and threats that will impact the Australian oncology market as a whole and the Top 20 in particular
*Quantify the future size and scope of the Top 20 Australian cancer therapies market and predict the performance of its key compounds
*Understand critical success factors in growing and defending cancer brand franchises from new entrants and generics
Table of Contents :
"ABOUT HEALTHCARE 2
About the Oncology pharmaceutical analysis team 2
CHAPTER 1 EXECUTIVE SUMMARY 3
Strategic scoping and focus 3
insight into the oncology market 3
Related reports 5
Upcoming related reports 6
CHAPTER 2 MARKET DEFINITION 8
Market definition for this report 8
Key data assumptions 9
Accounting for missing Pharmatel Fresenius Kabi sales 9
Split of rituximab sales 13
CHAPTER 3 MARKET OVERVIEW 14
Current and future market overview 14
The molecular targeted therapies class will continue to dominate 17
Herceptin will surrender its leading position to Rituxan/MabThera by 2018 18
Opportunities 20
The number of Australian cancer patients is on the rise, with prostate and breast cancer being most common 20
End-of-life debate highlights need for more funding of high-cost oncology drugs 22
National screening programs aim to detect cancer in early stages 23
Government grants support local cancer research 23
Expensive oncology products are financed by government- and company-backed programs 24
Threats 24
Health reforms aim to lower cancer expenditure 24
The Intravenous Chemotherapy Supply Program is feared to affect pharmacists' reimbursement 25
The impending impact of biosimilars 26
Novel drugs may struggle to get on the Pharmaceutical Benefits Scheme, as Erbitux's case shows 28
CHAPTER 4 BRAND DYNAMICS OVERVIEW 30
Overview of competitive landscape 30
Reimbursement is a key driver of brand choice 30
Special programs fund the use of certain oncology drugs 33
The Chemotherapy Pharmaceuticals Access Program 34
The Herceptin Program 35
Herceptin via the Special Authority Program 37
Risk-sharing agreements 38
CHAPTER 5 BRAND DYNAMICS - MOLECULAR TARGETED THERAPIES 39
Herceptin (trastuzumab; Roche) 39
Drug profile 39
Product positioning 42
HER-2-positive breast cancer 42
SWOT analysis 43
Brand forecast to 2018 43
Launch of subcutaneous formulation may have small impact on sales 44
New clinical trial data may drive use in adjuvant breast cancer setting 45
Approval for neoadjuvant treatment of breast cancer 46
Herceptin's approval in gastric cancer would be first indication outside breast cancer 46
Further uptake of Tykerb/Tyverb in HER-2-positive breast cancer will impact Herceptin's revenues 47
Uptake of biosimilar trastuzumab products 51
Glivec/Gleevec (imatinib; Novartis) 52
Drug profile 53
Product positioning 56
Chronic myeloid leukemia (CML) 56
Gastrointestinal stromal tumors (GIST) 59
Acute lymphoblastic leukemia (ALL) 60
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