Drug Screening Technology Changes Affect The Global Pharmaceutical Market - Injection Plastic

Over the years, the global pharmaceutical company focused on research and development

on the faster and better develop the technology for clinical drugs are very interested, and whom continue to work very hard. Unfortunately, the discovery process was considered to be more reasonable and more effective technology is not able to achieve its original vision. The fact is, despite the annual increase in the cost of drug development, but the real into the market without a commensurate number of new products known for. This makes a number of pharmaceutical companies have to rethink the way in what to filter the drug, while considering whether to intervene directly to the development of the whole process.

High-throughput screening of Solomon

Of the last century until the mid-90s, drug discovery is mainly through high-throughput screening (HTS). Be regarded as the original high-throughput screening of various heavy pharmacological activity in vitro and in vivo experiments a reasonable substitute, which is heavily dependent on liquid handling robotic devices, automated test equipment and computer control to study the new interest in biological target molecules and between interaction. And high-throughput screening is used to match the so-called combinatorial chemistry.

Combinatorial chemistry method excludes the study of individual compounds, the traditional method, and replaced the same time of hundreds or even thousands of laboratory synthesized and stored in a large database of compounds. Combinatorial chemistry methods De Chu Xian, gave birth to the birth of new companies, these companies only mission is to create a combinatorial library, and then transferred to the Drug Discovery, Gong interest of these companies target Jinxingshaixuan. Therefore, if there is no high-throughput screening technology, can not be such a huge number of compounds screened, the application of high throughput screening process to further promote the development of other aspects of progress.

It is worth mentioning that the completion of human genome projects, technological advances, such as more compact (from the original 96-well plates, grown to 384,1536 and even 456 well plates), but also help maintain the HTS technology as the main driving force for drug discovery . Other technological advances (including the new sense of technology) such as quantitative protein drug candidates, when combined with changes in the differential scanning calorimetry or light scattering measurements.

However, looking for new active molecules, the production of high-throughput screening is difficult to cope with the large number of additional data, it is not more than the needle in a haystack. This allows pharmaceutical companies to squeeze them in many high-throughput screening program. For the pharmaceutical industry, possible alternative strategy is to acquire permits and development of similar drugs, but the technical terms are likely to turn high content screening (HCS).

High-content drug screening is essentially a simplified method for drug discovery, but it is about a specific molecule with a specific receptor or enzyme interactions can be very effective there. For example, receptors and enzymes can not exist in isolation, but they are complex cellular responses and interaction part of the environment, high-content drug screening by Shi Yong Huo cell basis as a drug discovery to address this issue, therefore, the technology of another name is cell-based screening. High-content drug screening defining characteristic is not observed drug candidates at a particular time instant on the subject of the role of a single target, but the use of a single instrument can work in a space and time, number of cells within the tracking process. The process involves a protein changes, such as G-protein coupled receptor (GPCR) signal transduction, kinase-mediated signal transduction and ion channel signal transduction. For example, GPCR activation can stimulate them into the cell. As mentioned earlier, this process is visible, thus providing a specific objective to measure the efficiency of drug candidates.

Cell electrolysis spectrum rivalry

Although the original high-content drug screening identified by the fluorescence determination, but other technologies such as cell electrolysis measured spectrum appears, for some processes provided a better choice. It does not require agents or other types of fluorescent markers for cell marking, and can also detect a number of cell signaling channel. At present, this technology is relatively low flux limit for the occasion, but the equipment manufacturers to increase throughput. In fact, the high content drug screening can also be used for nucleic acid-based processes, such as DNA transcription or RNA interference, as well as cellular processes such as apoptosis, DNA damage repair or cell division occurs. Obviously, these cases require different method. For example, can be assayed for DNA degradation assessment of apoptosis.

High content drug screening is facing a major problem, because it is a kind of image-based technology, it can produce large amounts of data. For example, a single experiment can generate up to 10TB [trillion bytes; 1TB = 1000GB] data. Currently, vendors are developing to deal with PB level (1PB = 1000TB) quantitative data equipment, all these data must be processed and stored, Xianran this Yaoqiu high content of drug screening have vast computing power. Of course there are many other challenges, such as the need to develop new methods to measure a particular cell type of interest (such as immune system cells) in the process.

Nevertheless, the advantages of high content drug screening seems better than its shortcomings. The most significant advantage is that, compared with the traditional determination, it was more useful information. High content screening data, the composition of space and time means that it studies than the traditional one-dimensional HTS data more biological significance, and can draw from the relationship between morphological changes. High content drug screening Another important attraction is its economy, especially in the current global financial crisis, this is an important consideration. It can lower the cost of traditional methods to obtain large amounts of information. In addition, the high content drug screening is also used in the discovery process toxicological data early is crucial to help the development of the drug candidates have the problem sorted and toxicity of compounds removed as soon as possible to reduce the subsequent demand for animal testing, due to high content drug screening is based on whole-cell research, so it can generate all animal experiments can only be provided by the data.

by: gaga

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