subject: Finally- Fibromyalgia, Chronic Fatigue Syndrome (cfs), Lupus, Autoimmune Disease Linked To Infection [print this page] ==> Idiopathic Disease Easy Explanation But is it the Right One?
Idiopathic disease, one that presents without any definitive causes, can have recognizable signs and symptoms. It remains the causality; however, that troubles medical schools, private practices, and hospitals. Only pharmaceutical companies benefit from ongoing symptom treatments ordered for CFS, Lupus, Autoimmune disease, and Fibromyalgia. These can total in the billions every year.
==> Proposed Non-idiopathic Causes for CFS and Fibromyalgia
==> Brain abnormalities
==> Genetic factors (HPA) axis
==> A hyper-reactive immune system
==> Viral or other infectious agents like (Chronic Lyme disease Complex)
==> Psychiatric or emotional conditions
==> Fibromyalgia and CFS - Are Genetics to Blame?
CFS and Fibromyalgia have been linked with genes involved in the hypothalamic-pituitary-adrenal (HPA) axis as well as the sympathetic nervous system. These genes regulate response to trauma, injury, and other stressful events. After ten years of ongoing clinical experience, Envita is confident that while such traumas could play a role in these diseases etiology, they are likely not the causes.
==> What is the HPA (Hypothalamic-pituitary- adrenal axis)?
HPA comprises a complex set of direct influences and feedback interactions among the hypothalamus, the pituitary gland (a pea-shaped structure located below the hypothalamus), and the adrenal, also called "suprarenal glands - small, conical organs atop of the kidneys.
The interactions among these organs constitute the HPA axis, a major part of the neuroendocrine system that controls reactions to stress and regulates many body processes including digestion, the immune system, mood and emotions, sexuality, as well as energy storage and expenditure. Infectious disease, such as chronic Lyme disease Complex, impacts the HPA-axis via neurotoxins that compete for the same receptor sites used by the HPA-axis. In fact, such infections can bring about identical symptoms of some idiopathic disease and many of the symptoms associated therewith. This should bring our attention that complex of infections such as Lyme Disease Complex that is composed of a number of infections and neurotoxins bring about all the same symptoms and more.
==> Does HPA Affect Fibromyalgia or CFS?
Abnormal levels of certain chemicals regulated by the hypothalamus-pituitary-adrenal (HPA) axis have been proposed as a potential cause of Chronic Fatigue Syndrome. It has also been cited as being related to Fibromyalgia. This HPA system controls important functions including sleep, stress response, and depression. Of particular interest to researchers are the following chemicals and other factors controlled by the HPA axis as it pertains to the neurobiology of mood disorders and functional illnesses:
==> anxiety disorder
==> bipolar disorder
==> insomnia
==> post-traumatic stress disorder
==> borderline personality disorder
==> ADHD
==> major depressive disorder
==> burnout
==> CFS
==> Fibromyalgia
==> irritable bowel syndrome
==> alcoholism
==> Antidepressants, which are routinely prescribed for many of these illnesses, serve to regulate HPA axis function. All of these conditions and their symptoms are commonly seen in Chronic Lyme disease patients that contain a host of infections and neurotoxins.
==> Can Chronic Lyme disease Complex or Infectious Disease Affect HPA?
Patients may contract an infection at any point in their life-time; however, the symptoms of Chronic Lyme disease Complex or its co-infections may remain unseen or dormant until the individual is weakened by a trauma. This could be anything ranging from child birth or injury (like car accident) to something like the death of someone close, a divorce, or even a vaccine (as seen among children with weakened immune systems.)
In the etiology of chronic infectious disease, the traumatic event is a trigger but not the cause of Autoimmune disease, Chronic Fatigue Syndrome, or Fibromyalgia. Nevertheless, treating these triggers is critically important to patient care. It seems that infection, rather than genetic defects, is the progenitor of HPA axis disruption.
==> Major Impact of Epigenetic Changes
Studies show that gene alterations are caused by infections involving immune function, intercellular communication, and energy transfer.
Researchers have identified many different genes in patients with Chronic Fatigue Syndrome that relate to blood disease, immune system function, and infection. Despite these identifications, however, there is no clear pattern to them and it is quite possible that infection alone that is altering these genes. In the same vein, they are likely responsible for impacting mental and emotional health as well. It is very possible that infections can alter these genes that impact both mental and emotional health as well.
==> Important Neurotransmitters Changed by Neurotoxins Compete for Receptor Sites
Some CFS patients have shown abnormally high levels of serotonin - a neurotransmitter (chemical messenger in the brain). Conversely, they also often show deficiencies in dopamine - an important neurotransmitter associated with feelings of reward. In some cases there is also a demonstrable imbalance between norepinephrine and dopamine.
Similarly those with CFS have demonstrated lower levels of cortisol - a stress hormone produced by the adrenal glands. It has been suggested that such cortisol deficiencies are responsible for Chronic Fatigue Syndrome patients having impaired or weakened responses to psychological or physical stresses like worry, infection, or exercise. However, administering replacement cortisol improves symptoms only in some. Why such inconsistency in treatment response? Because in order for the patient to get well, infections as well as toxins (neurotoxins) must be cleared before hormone replacement can begin to take effect.
==> Idiopathic Diseases at Root of Many Psychological Disorders Sleep Disorders
Certain CFS, Fibromyalgia, and Autoimmune patients have disturbed circadian rhythms (disorder of the sleep-wake cycle), which is regulated by the "circadian clock," a nerve cluster in the HPA axis. These are commonly seen is Lyme Disease Complex among a number of other neurological symptoms.
A mentally or physically stressful event, such as a viral infection, may disrupt natural circadian rhythms, and an inability to reset them can result in a chronic sleep disturbance cycle. Medications that improve sleep can be very helpful for certain patients with Chronic Fatigue Syndrome, Fibromyalgia, and Autoimmune diseases; but not until the infections are cleared and hormones are rebalanced, can long-term improvement be expected.
Psychological, personality, and social factors are also strongly related to Chronic Fatigue Syndrome, Fibromyalgia, and Autoimmune disease such Lupus. There is a decidedly complex relationship between physical and emotional factors.
==> What Specific Infections are Responsible
Because most of the features of Chronic Fatigue Syndrome resemble those of a lingering viral illness, many researchers have focused on the possibility that a virus or some other infectious agent causes the syndrome in some cases.
At Envita we have clinically determined that these patients usually have a group of viral, bacterial, parasitic, and fungal infections that make up what we call Lyme disease Complex. Some patients may or may not have actual Lyme disease but they may have other tick-borne illness and their co-infections that have brought about immunological, hormonal, and neuroendocrine changes.
Still, not all Chronic Fatigue Syndrome patients show signs of infection. And although experts have long been divided on whether infections play any role in this disorder at all, it does seem clear that subtypes of both viral and non-viral Chronic Fatigue Syndrome exist. That being said, researchers have seemingly overlooked the complexity of mute-infections, multi-toxins, and heavy metal components that complicate these conditions making them extremely difficult to diagnose on a case to case basis. To be certain most patients are never tested thoroughly and correctly for all the infections that make up, chronic Lyme Disease Complex.
==> Infections Looking More Like the Cause
The theory for Chronic Fatigue Syndrome having a viral cause is not based on hard evidence, rather, on an ever-growing series of observations that suggest this association:
Chronic Fatigue Syndrome as well as Fibromyalgia and Autoimmune disease patients are often found with elevated levels of antibodies to many organisms that cause fatigue and other Chronic Fatigue Syndrome symptoms. Such organisms include those that cause Lyme disease, Candida ("yeast infection"), herpes virus type 6 (HHV-6), human T cell lymph tropic virus (HTLV), Epstein-Barr, measles, coxsackie B, cytomegalovirus, or parvovirus.
Many of these infectious agents are very common, however, and none has emerged as a definitive cause of CFS. Well-designed studies of patients who met strict criteria for CFS without any known cause have not found an increased incidence of any specific infection(s).
In up to 80% of cases, CFS starts suddenly with a flu-like condition. In the U.S., there have been reports of cluster outbreaks of CFS occurring within the same household, workplace, and community (but most have not been confirmed by the Centers for Disease Control and Prevention). However, most cases of CFS occur sporadically in individuals, and do not appear to be contagious. These all have the pattern of infections and more importantly community of infections taking over the patients immune system, which is clearly seen in the depressed CD57 markers found in almost all of this population.
==> Immune System Abnormalities and Immunocompromised States
==> Complex of Infections Decreases Immune Function
CFS is sometimes referred to as "chronic fatigue immune dysfunction syndrome." In many cases, studies have detected many immune system irregularities. Some components appear to be over-reactive, while others appear to be under-reactive, but no consistent picture has emerged to explain CFS as a disease of the immune system.
==> Environmental Toxins Impact Chronic Fatigue Syndrome and Fibromyalgia
Some studies have reported that a majority of CFS patients have allergies to foods, pollen, metals (such as nickel or mercury), or other substances. One theory is that allergens, like viral infections, may trigger a cascade of immune abnormalities leading to CFS. However, most allergic people do not have CFS.
==> Autoimmunity Overlaps with Conditions
The risk profile for CFS is similar to the risk profiles for a number of autoimmune diseases. Studies are inconsistent, however, in reporting the presence of autoantibodies (antibodies that attack the body's own tissues) in CFS, and the disease is unlikely to be due to autoimmunity making it more likely connected to infectious disease.
==> Where Can You Find Help?
Envita Medical Centers has been leading the way in comprehensive, personalized patient care. Contact us for more information. Get your health and life back stop treating symptoms and let us help get to the cause in the immediate.
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