subject: Minoxidil Can Directly Promote The Proliferation Of Hair Matrix Cells And Outer Root Sheath Melanocy [print this page] Disappearance of epidermal melanocytes at vitiligo lesions has been confirmed. Thus, in the restoration of this disease, the melanocytes are from the hair root sheath and hair matrix melanocytes, hair follicles below the headland ministry. Melanocytes in the outer root sheath are not activated melanocytes. The study finds that minoxidil can directly promote the proliferation of hair matrix cells and outer root sheath melanocytes. Minoxidil can also make the dermal papilla cells secreted biologically active substances to adjust the growth of hair follicle. It may be efficacy factor for minoxidils treatment in vitiligo.
Recent studies have shown that vitiligo pathogenesis may be melanocyte autoimmune injury. The Halometasone super efficient sugar quality hormones, with its treatment of vitiligo, the total effective rate of 80% to 90%, 65.8% effective rate of Halometasone Cream treatment of vitiligo vulgaris, confirmed that the effect of the treatment of vitiligo Halometasone does significant, but with separate treatment with 5% minoxidil, the difference was not significant. Main adverse reactions topical Halometasone alone for long-term application is easy to cause folliculitis-like lesions, mild skin atrophy, the cream of Halometasone and 5% minoxidil tincture combined topical treatment of vitiligo, the effective rate of 93.3 percent, far higher does not affect the separate topical Halometasone Cream 5% minoxidil tincture of 65.8% and 59.5%, and side effects are less severe with continued therapy.
Speculated that the possible mechanism: as immunosuppressive agents, Halometasone can improve the status of the local immune from the anti-inflammatory, anti-allergic effects to avoid neonatal melanocytes and the activity of melanocytes progress of damage, to terminate the development of vitiligo and promote the melanocytes recovery; Halometasone,, minoxidil may have direct effect on melanocytes to stimulate melanogenesis and induction of skin lesions returned to normal color; Halometasone can reduce the 5% minoxidil allergy adverse reactions and strong stimulation to promote undifferentiated melanocytes mature, the proliferation of unique pharmacological effects can be play with the hair follicle root sheath. Both played a synergistic effect was significantly higher than the other two groups, fewer adverse reactions and good patient tolerance. It is worth to promote the use in clinical work.
Minoxidil-based drug can treat various kinds of hair loss. It will promote regeneration of hair loss. The penetrant makes breakthroughs in traditional ethanol and propylene glycol. It can effectively suppress the allergic phenomena and side effects. Minoxidils hair loss treatment mechanism is not entirely the role of the dilation of blood vessels. The study from cosmetic raw material suppliers suggests that minoxidil maintains the growth of hair follicles and dermal papilla blood vessel formation and function by cytokine stimulation. Thus it plays an important role in the treatment of hair loss and it is worthy of recommendation. Topical minoxidil can promote hair loss and the efficacy of the regeneration has been recognized by all countries in the world. Its adverse reactions are rare.Source:http://www.cosprm.com
by: anelwew
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